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US 5,035,894 AGranted
Controlled release compositions and transdermal drug delivery device
AssigneeDow Corning Corporation
InventorsChi-Long Lee, Katherine L. Ulman
Life of this patent
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Abstract
Adhesive compositions comprising blends of polyethylene oxide-grafted silicone polymers with resinous copolymers are disclosed. The adhesive compositions enhance release, in a controlled fashion, of bioactive or chemical agents blended or otherwise dispersed through the compositions. Transdermal drug delivery devices incorporating the adhesive compositions are also disclosed.
Claims39
A controlled release composition comprising:
- (1) a pressure sensitive adhesive composition consisting essentially of
- (A) about 10 to 99 wt. % of a random graft copolymer having the average formula ##STR8## wherein x/y is in the range of 0.01 to 100, inclusive;
- x+y is in the range of 10 to 1000, inclusive;
- z is a number less than or equal to 15;
- R is selected from the group consisting of alkyl radicals having 1 to 8 carbon atoms, aryl radicals, and haloalkyl radicals;
- all R groups can be the same or different;
- M is hydrogen, --COCH.dbd.CH.sub.2, or --CO--NH(CH.sub.2).sub.2 --O--CO--C(CH.sub.3).dbd.CH.sub.2 ;
- G is a divalent radical selected from --CH.sub.2 CH.sub.2 CH.sub.2 O--, --CH.sub.2 CH.sub.2 O--, or urethane groups;
- and
- (B) correspondingly about 1 to 90 wt. % of a random resinous copolymer consisting essentially of structural units of the formula (R.sup.3).sub.3 SiO.sub.0.5 and SiO.sub.2, wherein R.sup.3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionally of at least about 0.5 wt. %;
- and
- (2) a bioactive or chemical agent dispersed through said pressure sensitive adhesive composition.
9 more elements
Dependencies are inferred from the claim text.