Variant of LAV viruses
AssigneeInstitut Pasteur
InventorsMarc Alizon, Pierre Sonigo, Simon Wain-Hobson, Luc Montagnier
Life of this patent
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Abstract
A variant of the LAV virus, designated LAV.sub.MAL and capable of causing AIDS. The cDNA and antigens of the LAV.sub.MAL virus can be used for the diagnosis of AIDS and pre-AIDS.
Claims20
An isolated or synthetic peptide comprising an amino acid sequence that is a fragment of the following amino acid sequence:
- ##STR1## wherein, in said amino acid sequence, A is alanine, C is cysteine, D is aspartic acid, E is glutamic acid, F is phenylalanine, G is glycine, H is histidine, I is isoleucine, K is lysine, L is leucine, M is methionine, N is asparagine, P is proline, Q is glutamine, R is arginine, S is serine, T is threonine, V is valine, W is tryptophan, and Y is tyrosine,
- and wherein said fragment comprises at least one amino acid sequence selected from the group consisting of amino-acyl residue 37-130, amino-acyl residues 211-289, amino-acyl residues 488-530, amino-acyl residues 490-620, amino-acyl residues 680-700, amino-acyl residues 1-530, amino-acyl residues 34-530, amino-acyl residues 531-877 of an envelope glycoprotein of LAV.sub.MAL virus.
An isolated or synthetic peptide comprising an amino acid sequence that is a fragment of the following amino acid sequence:
- ##STR2## wherein, in said amino acid sequence, A is alanine, C is cysteine, D is aspartic acid, E is glutamic acid, F is phenylalanine, G is glycine, H is histidine, I is isoleucine, K is lysine, L is leucine, M is methionine, N is asparagine, P is proline, Q is glutamine, R is arginine, S is serine, T is threonine, V is valine, W is tryptophan, and Y is tyrosine,
- and wherein said fragment comprises a p25 peptide comprising amino-acyl residues 138-385 of gag protein of LAV.sub.MAL virus.
An isolated or synthetic peptide comprising an amino acid sequence that is a fragment of the following amino acid sequence:
- ##STR3## wherein, in said amino acid sequence, A is alanine, C is cysteine, D is aspartic acid, E is glutamic acid, F is phenylalanine, G is glycine, H is histidine, I is isoleucine, K is lysine, L is leucine, M is methionine, N is asparagine, P is proline, Q is glutamine, R is arginine, S is serine, T is threonine, V is valine, W is tryptophan, and Y is tyrosine,
- and wherein said fragment comprises a p13 peptide comprising amino-acyl residues 385-519 of gag protein of LAV.sub.MAL virus.
An isolated or synthetic peptide comprising an amino acid sequence:
- ##STR4## wherein, in said amino acid sequence, A is alanine, C is cysteine, D is aspartic acid, E is glutamic acid, F is phenylalanine, G is glycine, H is histidine, I is isoleucine, K is lysine, L is leucine, M is methionine, N is asparagine, P is proline, Q is glutamine, R is arginine, S is serine, T is threonine, V is valine, W is tryptophan, and Y is tyrosine.
Dependencies are inferred from the claim text.