Intranasally applicable powdery pharmaceutical composition
AssigneeTeljin Limited
InventorsKunio Sekine, Daisuke Araki, Yoshiki Suzuki
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Abstract
An intranasally applicable powdery pharmaceutical composition comprising a polypeptide having a physiological activity, a quaternary ammonium compound, and a lower alkyl ether of cellulose. This powdery pharmaceutical composition has an excellent preservability and chemical stability of the polypeptides and, when the powdery composition is administered to the nasal cavity in the form of a spray, the polypeptides are effectively absorbed through the nasal mucosa.
Claims12
An intranasally applicable powdery pharmaceutical composition comprising a pharmaceutically effective amount of a polypeptide having a physiological activity and about 0.001% to 12% by weight, based on the total weight of the composition, of at least one quaternary ammonium compound selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetyl trimethyl ammonium bromide, and dodecyl dimethyl ammonium bromide in at least one lower alkyl ether of cellulose selected from the group consisting of hydroxypropyl cellulose, methyl cellulose, hydroxyethyl cellulose and hydroxpropylmethyl cellulose.
Dependencies are inferred from the claim text.