Micro-capsules
AssigneeBiogram AB
InventorsBo M. Ekman, Kare V. Larsson, Ake R. Lindahl, Ulf S. E. Rothman
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AssigneeBiogram AB
InventorsBo M. Ekman, Kare V. Larsson, Ake R. Lindahl, Ulf S. E. Rothman
Estimating the term…
The invention relates to a completely novel type of micro-capsules, viz. such capsules where an encapsulated hydrophobic or lipophilic substance is surrounded by polar solid crystals of polar lipids which expose their hydrophilic face outwards and their hydrophobic face turned inwards towards the hydrophobic or lipophilic substance. These micro-capsules can be utilized to encapsulate for instance tacky substances or substances to be protected against oxidation or influence from light. Moreover, an especially interesting use according to the invention is the use of said micro-capsules in an ointment base, where the active ingredient is well protected within said capsules up to the use but which at the application on the skin directly comes into contact with the skin surface as a consequence of the crystalline structure of the shell. Furthermore, the invention relates to a special micro-capsule composition in the form of a dispersion of said micro-capsules in water or a polar liquid, where the crystals constitute 5-50 percent by weight and water or the polar liquid 50-95 percent by weight. Moreover, the invention relates to a process for the preparation of said micro-capsules, wherein a mixture of said polar lipid with water or polar liquid is formed, the mixture is heated above the transition temperature of the lipid and the mixture is then cooled to the desired temperature so as to obtain crystallization, the hydrophobic or lipophilic substance being added before or during the lipophilic phase. Finally, the invention relates to a crystal dispersion of the polar lipid in a polar liquid, such as glycerol, ethylene- or propylene glycol.
A micro-capsule composition consisting essentially of a hydrophobic or lipophilic substance surrounded by surface-active solid crystals of polar lipids, which crystals have a hydrophilic side that is exposed outwards and a hydrophobic side that is turned inwards toward the hydrophobic or lipophilic substance.
A crystal dispersion of a polar lipid in a polar liquid other than water, wherein the dispersion consists essentially of a dispersion of the polar lipid in a polar liquid other than water and having the ability of forming polar solid crystals of the polar lipid where the polar liquid constitutes from about 50 to 95 percent by weight of the dispersion, and where the molecular orientation of the polar lipid within the crystal is such that the crystal surface consists essentially of polar end groups of the lipid, which impart hydrophilic properties to said crystals.
Dependencies are inferred from the claim text.