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US 4,898,920 AGranted
Adhesive compositions, controlled release compositions and transdermal delivery device
AssigneeDow Corning Corporation
InventorsChi-Long Lee, Katherine L. Ulman
Life of this patent
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Abstract
Adhesive compositions comprising blends of polyethylene oxide-grafted silicone polymers with resinous copolymers are disclosed. The adhesive compositions enhance release, in a controlled fashion, of bioactive or chemical agents blended or otherwise dispersed through the compositions. Transdermal drug delivery devices incorporating the adhesive compositions are also disclosed.
Claims24
An adhesive composition consisting essentially of a blend of
- (A) about 10 to 99 wt. % of said composition of a random graft copolymer having the average formula ##STR8## wherein x/y is in the range of 0.01 to 100, inclusive;
- x+y is in the range of 10 to 1000, inclusive;
- z is a number less than or equal to 15;
- R is selected from the group consisting of alkyl radicals having 1 to 8 carbon atoms, aryl radicals and haloalkyl radicals;
- all R groups can be the same or different;
- M is H, --COCH.dbd.CH.sub.2, or --CO--NH(CH.sub.2).sub.2 --O--CO--C(CH.sub.3).dbd.CH.sub.2 ;
- G is a divalent radical selected from --CH.sub.2 CH.sub.2 CH.sub.2 O--, --CH.sub.2 CH.sub.2 O--, or urethane groups;
- and
- (B) correspondingly I to 90 wt. % of a random resinous copolymer consisting essentially of structural units having the formulae R.sub.3.sup.3 SiO.sub.0.5 and SiO.sub.2 wherein R.sup.3 is a monovalent hydrocarbon radical, said resinous copolymer having an SiOH functionality of at least about 0.5 wt. %.
6 more elements
Dependencies are inferred from the claim text.