Oncornavirus vaccines and feline alpha-type interferon
AssigneeThe Regents of the University of California
InventorsNeils C. Pedersen, Janet Yamamoto
Life of this patent
Estimating the term…
Abstract
Retroviral vaccines are provided comprising incompetent retroviruses containing defective RNA produced by growing viral transformed cells in the presence of interferon. The resulting defective viruses by themselves or in combination with interferon can be used as vaccines for immunizing viral sensitive hosts against infection. A novel feline interferon is produced in culture with cells infected with the defective non-infectious retroviruses.
Claims9
A method for producing a retroviral vaccine form a B-type or C-type retrovirus, said method comprising:
- growing mammalian host cells infected with said retrovirus in the presence of interferon for a sufficient time for incompetent retrovirus particles to bud from said cells;
- and
- harvesting said retrovirus particles for use as a vaccine.
A method for producing a retroviral vaccine from a C-type retrovirus, said method comprising:
- growing mammalian host lymphocyte cells infected with said retrovirus in the presence of at least 100U/ml alpha-interferon for a sufficient time for incompetant retrovirus particles to bud from said cells;
- and
- harvesting said retrovirus particles for use as a vaccine.
Dependencies are inferred from the claim text.