US 4,834,890 AGranted

Centrifugation pheresis system

AssigneeBaxter International Inc.

InventorsRichard I. Brown, Sidney Smith, David E. Cerny, John T. Foley

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Abstract

A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis. The platelet rich plasma is separated from the residual red blood cells in a first part. The platelet rich plasma flows into the second part and is separated into platelet poor plasma and platelets. The platelet poor plasma can be drawn off and returned to a donor or collected. The platelet concentrate can then be accumulated in a separate container.

Claims18

Dependent claims

A method of separating a selected component from a fluid comprising:

providing an elongated, flexible separation member with an input port and at least one output port with a flow path therebetween a first substantially non-rotatable, fluid flow conduit in fluid flow communication with the input port and a second, substantially non-rotatable, fluid flow conduit in fluid flow communication with the at least one output port;
providing a centrifuge with a hollow cylindrical receiving chamber;
placing the separation member into the receiving chamber adjacent an interior, curved, circular peripheral wall thereof;
positioning a free, distal end of the first conduit and a free distal end of the second conduit outside of the centrifuge;
rotating the centrifuge, including the receiving chamber, while simultaneously holding the distal ends fixed, providing an input fluid flow at the fixed distal end of the first fluid flow conduit and at least partly filling the elongated separation member therewith;
providing a flow path constricting interface surface, adjacent a part of the flow path, oriented at a selected angle with respect to the fluid flow;
separating by centrifugation, at least the selected component, in a portion of the fluid in the separation member;
forming a fluid interface between a portion of the separated component and a portion of the residual fluid adjacent the provided selectively oriented interface surface;
and
sensing the location of the fluid interface with respect to the interface surface and withdrawing a portion of the separated component through the output port, via the second fluid flow conduit, and out the fixed distal end thereof in response to the interface being sensed at a predetermined location.

7 more elements

A system for separating a selected fluid component in a fluid from an exterior source, the system comprising:

means for centrifugation including means defining a rotatable, generally cylindrical, receiving member with said member defining an annular slot;
and a closed fluid transfer system including,
an elongated, hollow, flexible fluid flow separation member defining a fluid input port, a residual fluid output port and a selected component output port, and defining a fluid flow region between at least said fluid input port and said selected component output port first, second and third flexible, substantially non-rotatable tubing members each with first and second ends, said tubing members coupled at respective of said first end to said input port, said residual output port and said component output port, said separation member being slidable receivable within said annular slot with said second ends locatable at a fixed region outside of said rotatable member,
said separation member positioned in said slot in a generally cylindrical shape,
a fluid flow restricting interface surface carried adjacent said fluid flow region and oriented at a selected angle to a fluid flow from said input port to said selected component output port;
and
means for detecting the presence of an interface between the separated selected component and the remaining fluid adjacent a region of said interface means.

4 more elements

Dependencies are inferred from the claim text.