Ultra - rapid plasma freezing with halocarbon heat transfer liquids
AssigneeCastleton, Inc.
InventorsPhilip H. Coelho, Victor Comerchero
Life of this patent
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Abstract
Ultra rapid freezing of thin wall containers, preferably plastic bags or bottles, of blood plasma by direct contact with a low freezing temperature liquid mixture of a chlorofluorocarbon (CFC 113) and at least one of a group of fluorocarbons minimizes migration of toxins in the heat transfer liquid to the plasma and improves the percentage yield of blood soluble protein fractions extracted from the frozen plasma in a subsequent freeze drying process.
Claims7
A process of freezing plasma comprising the steps of exposing thin wall containers of plasma to be frozen to direct contact with a heat transfer liquid selected from the group consisting of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (CFC 113) and mixtures of the chlorofluorocarbon 1,1,2 trichloro-1,2,2 trifluoro-ethane (Freon 113), and at least one of the fluorocarbons perfluoropentane (C.sub.5 F.sub.12), perfluorohexane (C.sub.6 F.sub.14), perfluoromethylcyclohexane (C.sub.7 F.sub.14), perfluoroheptane (C.sub.7 F.sub.16), perfluoromonomethyldimethylcyclohexanes (C.sub.7 F.sub.14 /C.sub.8 F.sub.16), perfluorodecalin isomers (C.sub.10 F.sub.18), mixed perfluorodecalin and methyldecalin isomers (C.sub.10 F.sub.18 +C.sub.11 F.sub.20), and perfluorinated polyethers ([OCF(CF.sub.3)CF.sub.2 ].sub.n --(OCF.sub.2).sub.m, and maintaining said liquid at a temperature sufficiently low enough to freeze said plasma in the desired amount of time.
The process of any one of the preceding claims, wherein said heat transfer liquid is maintained at a temperature of -30.degree. C. or below.
Dependencies are inferred from the claim text.