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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorYoichiro Ito
Estimating the term…
A flow-through continuous countercurrent extraction system consisting of a coiled tube or spiral coplanar channel revolving around a main axis and rotating around its own axis at the same angular velocity and in the same direction. With two solvent phases A and B, there are 5 flow tubes: (1) a feed tube for phase B located at the head end of the column, (2) a return tube for phase A located at the head end, (3) a feed tube for phase A located at the tail end, (4) a return tube for phase B located at the tail end, and (5) a sample feed tube located at the middle portion of the column. The column is mounted on a hollow rotary shaft and the axis of revolution is defined by a stationary hollow central shaft. The 5 flow tubes are led through the hollow rotary shaft, and then through the stationary central shaft. In this way, the flow tubes from the rotary shaft are allowed to rotate freely without interference or twisting. Either a single column may be used, with a counterweight, or there may be two opposite columns operating simultaneously. The ingredients of the sample are separated according to the partition coefficients; when the partition coefficients favor phase A, the solutes are eluted through the head end, and when the partition coefficients favor phase B they may be eluted through the tail end, or they may be retained in the column when the partition coefficient fall between the above values. When the operation is aimed at enrichment and/or stripping of a particular substance or substances, the sample flow tube may not be used, and the sample solution is directly introduced through the head or tail feed tube, while the enriched or stripped solution is continuously collected through either the head or tail outlet tube.
A flow-through countercurrent chromatographic coil planet centrifuge system comprising means defining an axially rotatable coiled column having a head end and a tail end, means to rotate said column around its own axis and simultaneously and in the same angular direction and at the same angular velocity revolve the rotating column around an axis parallel to and spaced from its own axis, first phase feed conduit means connected to said column at a coil element adjacent to said head end, second phase feed conduit means connected to said column at a coil element adjacent to said tail end, second phase collection conduit means connected to said column at a coil element adjacent to said head end, first phase collection conduit means connected to said column at a coil element adjacent to said tail end, and sample-admission conduit means connected to said column at a coil element located at an intermediate portion of said column, for separating the phases in accordance with their densities and for separating components of a sample admitted through said sample-admission conduit means in accordance with the partition coefficients of said components.
A centrifugal separator comprising a separation bowl disposed generally horizontally, means to rotate said bowl about its own generally vertically disposed axis, means to simultaneously revolve said rotating bowl about another axis spaced from and parallel to said bowl axis, said means to rotate and said means to revolve said bowl causing said bowl to revolve and to rotate about said axes in the same angular direction and at the same angular velocity, and said bowl comprising means defining at least one coiled path for containing a sample to be separated by the composite centrifugal motion to which said bowl and said sample are subjected during use of said separator, wherein said coiled path defining means comprises a thin-walled tube of rectilinear cross-sectional shape spiral-wound in said bowl, and support means for said tube comprising filler material filling said bowl all around said tube to thereby support said tube therein.
A centrifugal separator comprising a separation bowl disposed generally horizontally, means to rotate said bowl about its own generally vertically disposed axis, means to simultaneously revolve said rotating bowl about another axis spaced from and parallel to said bowl axis, said means to rotate and said means to revolve said bowl causing said bowl to revolve and to rotate about said axes in the same angular direction and at the same angular velocity, and said bowl comprising means defining at least one coiled path for containing a sample to be separated by the composite centrifugal motion to which said bowl and said sample are subjected during use of said separator, wherein said bowl is a circular-disc-like member, and said path defining means comprises at least one channel integrally formed in said disc-like member.
A centrifugal separator comprising a separation bowl disposed generally horizontally, means to rotate said bowl about its own generally vertically disposed axis, means to simultaneously revolve said rotating bowl about another axis spaced from and parallel to said bowl axis, said means to rotate and said means to revolve said bowl causing said bowl to revolve and to rotate about said axes in the same angular direction and at the same angular velocity, and said bowl comprising means defining at least one coiled path for containing a sample to be separated by the composite centrifugal motion to which said bowl and said sample are subjected during use of said separator, wherein said centrifuge is used to separate the cells and plasma in blood, said path comprising a coiled column, and means to introduce a blood sample to be separated at a middle portion of said column, wherey said simultaneous rotating and revolving of said column causes cells to collect at one end of said column and plasma to collect at the other end of said column.
Dependencies are inferred from the claim text.