Loading patent…
AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsKanji Noda, Akira Nakagawa, Toshiharu Motomura, Hiroyuki Ide
Estimating the term…
A process for the preparation of an isoindoline derivative of the following general formula (II): ##STR1## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprises cycling a benzylidene derivative of the following general formula (I) ##STR2## wherein R.sup.1 is a hydrogen atom or lower alkyl group, and R.sup.2 and X are as defined above, in the presence of a reducing agent such as sodium boron hydride. In one embodiment, the benzylidene derivative may be substituted by a reaction mixture containing the same, the reaction mixture being prepared by reacting o-phthalaldehydic acid or its ester with an aniline derivative.
A process for preparing an isoindoline derivative represented by the following general formula (II) ##STR16## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprises
A process for preparing an isoindoline derivative represented by the following general formula (II) ##STR18## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprises
Dependencies are inferred from the claim text.