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US 4,400,511 AGranted
2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
AssigneeAmerican Home Products Corporation
InventorMeier E. Freed
Life of this patent
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Abstract
The compounds ##STR1## where R is hydrogen, alkyl, phenylalkyl or dialkylamino alkyl; R.sup.1 is hydrogen, alkyl or phenyl; X is --S-- or --NH-- A is hydrogen, acyl, aroyl, alkyl or substituted alkyl in which the substituent is alkoxycarbonyl or phenylalkyl; n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof are antihypertensive agents of the ACE inhibitor type.
Claims6
A compound of the formula ##STR5## in which R is hydrogen, alkyl of 1 to 6 carbon atoms, phenylalkyl of 7 to 12 carbon atoms, or dialkylaminoalkyl where each alkyl group has 1 to 6 carbon atoms;
- R.sup.1 is hydrogen, alkyl of 1 to 6 carbon atoms or phenyl;
- X is --S-- or --NH--;
- A is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxycarbonylalkyl in which each alkyl moiety has 1 to 6 carbon atoms, phenylalkyl of 7 to 12 carbon atoms, phenyl(alkoxycarbonyl)alkyl in which each alkyl group has 1 to 6 carbon atoms, alkanoyl of 2 to 7 carbon atoms, benzoyl or naphthoyl;
- and n is one of the integers 0, 1 or 2 or a pharmaceutically acceptable salt thereof.
1 more element
Dependencies are inferred from the claim text.