Novel rabies virus strain and a process for its preparation
AssigneeGist-Brocades N.V.
InventorGosse Bijlenga
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Abstract
A novel rabies virus strain No. 675 deposited in the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under number CNCTO AO 4/77, novel living or inactivated cell culture vaccines derived therefrom, a process for the isolation of the virus strain as well as a process for the preparation of the said vaccines and novel method of immunizing warm-blooded animals against rabies.
Claims3
A rabies virus strain exhibiting reproducibly significant cytopathic effect on in vitro cell cultures of primary or secondary SPF chicken embryo fibroblasts of strain No. 675 deposited with the Czechoslovak National Collection of Type Culture of the Institute of Hygiene and Epidemiology in Prague deposited under CNCTC AO 4/77.
Rabies virus strain novel species No. 675 deposited with the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague under CNCTC AO 4/77 distinguishable from the original HEP-Flury strain by
- (a) a very pronounced cytopathic effect
- (b) a shorter primary virus cycle
- (c) clearer and larger plaques
- (d) enhanced attaching capacity to the surface of cells
- (e) enhanced induction of interferon
- (f) higher virus-titres in culture
- (g) greater homogenicity of the strain
- (h) greatly reduced pathogenicity to a variety of mammals, and its mutants and variants exhibiting the above mentioned characteristics.
Dependencies are inferred from the claim text.