Antithrombotic treatment with quaternary ammonium sulfites and bisulfites
AssigneeT & R Chemicals, Inc.
InventorsJose A. Arias Alvarez, Ralph B. Thompson
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Abstract
Certain quaternary ammonium sulfites and bisulfites display anticoagulant and antithrombotic activity.
Claims17
A method for treating a thrombotic condition in a mammal comprising administering to said mammal an antithrombotically effective amount of at least one agent characterized by the formulas:
- ##STR3## wherein:
- R.sub.1, R.sub.2, R.sub.3, R.sup.4 are each an independently selected lower alkyl radical m and n are integers whose combined sum is equal to 2, and m is 0 or 1.
A method for treating a thrombotic condition comprising the step of orally feeding to a patient having a thrombotic condition from about 1 to 100 mg per kg of body weight per day in at least two spaced doses at least one agent having the formulas:
- ##STR4## wherein:
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each an independently selected lower alkyl radical, m and n are integers whose combined sum is equal to 2, and n is 0 or 1.
A method for treating a thrombotic condition comprising the steps of injecting into a patient having a thrombotic condition at a dose rate of from about 1 to 100 mg per kg of body weight per day in at least two spaced doses at least one agent having the formulas:
- ##STR5## where:
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each an independently selected lower alkyl radical, m and n are integers whose combined sum is equal to 2, and n is 0 or 1.
A method for preventing thrombosis of deep veins following surgery in a human patient comprising the step of treating said human patient post-operatively with an antithrombotically effective amount of at least one agent having the formula:
- ##STR6## where:
- R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each an independently selected lower alkyl radical, m and n are integers whose combined sum is equal to 2, and n is 0 or 1.
Dependencies are inferred from the claim text.