Antithrombotic treatment with organic amine sulfites and bisulfites

A method for treating a thrombotic condition comprising the step of orally feeding to a patient having a thrombotic condition from about 1 to 100 mg per kg of body weight per day in at least two spaced doses at least one agent having the formula:

• ##STR5## where:
• R.sub.1 is selected from the group consisting of lower alkyl radicals, cycloalkyl radicals containing from 6 to 10 carbon atoms each lower monohydroxyalkyl radicals, and aralkyl radicals,
• R.sub.2 is selected from the group consisting of lower alkyl radicals lower monohydroxyalkyl radicals, and hydrogen,
• R.sub.1 and R.sub.2 together can constitute a ring selected from the group consisting of morpholine, piperidine, and hexamethyleneimine, provided that each such ring can be substituted on one of its carbon atoms by a lower alkyl radical,
• R.sub.3 is selected from the group consisting of lower alkyl radicals lower monohydroxyalkyl radicals, hydrogen, and radicals of this formula:
• ##STR6## R.sub.4 is a divalent saturated lower aliphatic radical, m and n are integers, the sum of m and n is 2, and n is either 0 or 1.

A method for treating a thrombotic condition comprising the steps of injecting into a patient having a thrombotic condition at a dose rate of from about 1 to 100 mg per kg of body weight per day in at least two spaced doses at least one agent having the formula:

• ##STR7## where:
• R.sub.1 is selected from the group consisting of lower alkyl radicals, cycloalkyl radicals containing from 6 to 10 carbon atoms each, lower monohydroxyalkyl radicals, and aralkyl radicals,
• R.sub.2 is selected from the group consisting of lower alkyl radicals, lower monohydroxyalkyl radicals, and hydrogen,
• R.sub.1 and R.sub.2 together can constitute a ring selected from the group consisting of morpholine, piperidine, and hexamethyleneimine, provided that each such ring can be substituted on one of its carbon atoms by a lower alkyl radical,
• R.sub.3 is selected from the group consisting of lower alkyl radicals lower monohydroxyalkyl radicals, hydrogen, and radicals of this formula:
• ##STR8## R.sub.4 is a divalent saturated lower aliphatic radical m and n are integers, the sum of m and n is 2, and n is either 0 or 1.

A method for preventing thrombosis of deep veins following surgery in human patient comprising the step of treating said human patient post-operatively as a prophylaxis with an antithrombotically effective amount of at least one agent having the formula:

• ##STR9## where:
• R.sub.1 is selected from the group consisting of lower alkyl radicals, cycloalkyl radicals containing from 6 to 10 carbon atoms each, monohydroxyalkyl radicals, and aralkyl radicals,
• R.sub.2 is selected from the group consisting of lower alkyl radicals, lower monohydroxyalkyl radicals, and hydrogen,
• R.sub.1 and R.sub.2 together can constitute a ring selected from the group consisting of morpholine, piperidine, and hexamethyleneimine, provided that each such ring can be substituted on one of its carbon atoms by a lower alkyl radical,
• R.sub.3 is selected from this group consisting of lower alkyl radicals lower monohydroxyalkyl radicals, hydrogen, and radicals of this formula:
• ##STR10## R.sub.4 is a divalent saturated lower aliphatic radical, m and n are integers, the sum of m and n is 2, and n is either 0 or 1.