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AssigneeSumitomo Chemical Company, Limited
InventorsShunsuke Sami, Akihiko Sugie, Keiichi Ono, Hajime Kawakami, Atsuyuki Kojima, Junki Katsube
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A novel bicyclooctane derivative represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or C.sub.1-4 alkyl, X is ethylene or vinylene, and Y.sub.1 and Y.sub.2 are independently hydrogen or a hydroxyl-protecting group, or a pharmaceutically acceptable salt of said compound in which R.sub.1 is hydrogen. Said compound and pharmaceutically acceptable salt are chemically stable, have platelet anti-aggregation activity without undesirable pharmacological actions and exhibit the duration of high biological activity.
A compound of the formula:
2.beta.-[3'-(1-adamantyl)-3'.alpha.-hydroxy-trans-1'- propenyl]-3.alpha.-hydroxy-7-(4"-carboxy-1"E-butylidene)-cis-bicyclo[3,3,0] octane, and its stereoisomers (3'.beta. and/or 1"Z).
2.beta.-[3'-(1-adamantyl)-3'.alpha.-hydroxy-tran s-1'-propenyl]-3.alpha.-hydroxy-7-(4"-methoxycarbonyl-1"E-butylidene)-cis-b icyclo[3,3,0]octane, and its stereoisomers (3'.beta. and/or 1"Z).
2.beta.-[3'-(1-adamantyl)-3'.alpha.-hydroxypropyl]-3.alpha.-h ydroxy-7-(4"-carboxy-1"E-butylidene)-cis-bicyclo[3,3,0]octane, and its stereoisomers (3'.beta. and/or 1"Z).
2.beta.-[3'-(1-adamantyl)-3'.alph a.-hydroxy-trans-1'-propenyl]-3.alpha.-acetoxy-7-(4"-methoxycarbonyl-1"E-bu tylidene)-cis-bicyclo[3,3,0]octane and its stereoisomers (3'.beta. and/or 1"Z).
2. beta.-[3'-(1-adamantyl)-3'.alpha.-acetoxy-trans-1'-propenyl]-3.alpha.-aceto xy-7-(4"-methoxycarbonyl-1"E-butylidene)-cis-bicyclo[3,3,0]octane and its stereoisomers (3'.beta. and/or 1"Z).
2.beta.-[3'-(1-adamantyl)-3'.alph a.-acetoxy-trans-1'-propentyl]-3.alpha.-acetoxy-7-(4"-carboxy-1"E-butyliden e)-cis-bicyclo[3,3,0]octane and its stereoisomers (3'.beta. and/or 1"Z).
Dependencies are inferred from the claim text.