Pharmaceutical composition for the treatment of glaucoma
AssigneeKarl Thomae GmbH
InventorsHendricus C. Innemee, Jacobus C. A. van Meel, Adriaan De Jonge, Petrus B. M. W. M. Timmermans, Pieter A. van Zwieten
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Abstract
The method of treating glaucoma with compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxy-(alkyl of 1 to 4 carbon atoms), benzyl, halo-benzyl, methyl-benzyl, methoxy-benzyl or allyl; X is oxygen or sulfur; and n is 2 or, when X is sulfur, also 1; or non-toxic, pharmacologically acceptable acid addition salts thereof, and pharmaceutical compositions for use in said treatment.
Claims7
The method of treating glaucoma in a warm-blooded animal, which comprises topically administering to the affected eye of said animal an effective intraocular pressure reducing amount of a compound of the formula ##STR3## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms, hydroxy-(alkyl of 1 to 4 carbon atoms), benzyl, halo-benzyl, methyl-benzyl, methoxy-benzyl or allyl;
- X is oxygen or sulfur;
- and
- n is 2;
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.