Use of polypeptides as analgesic drugs
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsGerhard Zetler, Alessandro Rossi, Chiara De Paolis
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Abstract
A method of treating pain of whatever origin and nature in human and animal which comprises administering to the patient in need an effective amount of a polypeptide of structure: ##STR1## wherein X is selected from the group consisting of hydrogen, t-butyloxycarbonyl(Boc), Asp, Pyr-Glu, Pyr-Gln-Asp, Pyr-Asn-Asp; Y is selected from the group consisting of Thr, Met, Leu, Nle, Val; W is selected from the group consisting of Met, Nle, Leu.
Claims8
A method of inducing analgesia in animal and human patients suffering from severe pains selected from biliary and renal colic pains, pains caused by peripheral vascular diseases of the extremities, migraine, chronic pains in cancer diseases, post-operatory-, traumatological-, large burns-, myocardial infarction- and angina pectoris-pains, which comprises administering to the patient in need an effective amount of a polypeptide of the general structure:
- ##STR13## wherein X is selected from the group consisting of hydrogen, t-butyl-oxycarbonyl(Boc), Asp, Pyr-Glu, Pyr-Gln-Asp, Pyr-Asn-Asp;
- Y is selected from the group consisting of Thr, Met, Leu, Nle, Val;
- W is selected from the group consisting of Met, Nle, Leu.
Dependencies are inferred from the claim text.