Immunological preparations

An antigenic material in combination with a human lymphocyte antigen or a non-human, major hostocompatibility complex antigen which is analogous thereto, said human lymphocyte antigen or other major histocompatibility complex antigen itself being in the form of a complex with its associated B2-microglobulin protein or with a modified form of such protein which retains the epitope thereof intact and said antigenic material being attached to the B2-microglobulin of the complex through antibody thereto.

An immunological preparation for human or veterinary use comprising an antigenic material in combination with a major histocompatibility complex antigen which is itself in the form of a complex with a protein with which it is normally associated in nature or with a modified form of such protein which retains the epitope thereof intact, said antigenic material being attached to the protein of the complex through antibody to that protein, together with a physiologically acceptable diluent or carrier.

A process for preparing a combination of an antigen with a major histocompatibility complex antigen which comprises reacting together (1) a complex of the major histocompatibility complex antigen with a protein with which it is normally associated in nature or with a modified form of such protein which retains the epitope thereof intact and (2) a combination of said antigenic material with antibody against said protein.

A method for the production of an immunogenic response in a mammal or bird to an antigenic material which comprises administering thereto said antigenic material in combination with a major histocompatibility complex antigen which is itself in the form of a complex with a protein with which it is normally associated in nature or with a modified form of such protein which retains the epitope thereof intact, said antigenic material being attached to the protein of the complex through antibody to that protein.