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US 4,400,323 AGranted
3-[1-Hydroxyethyl]-4-carboxymethyl-azetidin-2-one
AssigneeMerck & Co., Inc.
InventorsBurton G. Christensen, Ronald W. Ratcliffe, Thomas N. Salzmann
Life of this patent
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Abstract
In a process for the total synthesis of thienamycin from L-aspartic acid via intermediate III: ##STR1## there is disclosed a process for preparing III via ##STR2## wherein R is a protecting group.
Claims2
The cis and trans isomers of a compound having the structure:
- ##STR48## wherein R is a readily removable blocking group selected from the group consisting of trialkylsilyl wherein the alkyl moieties have 1-6 carbon atoms each.
Dependencies are inferred from the claim text.