Back to results
US 4,399,290 AGranted
Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)heptanoates
AssigneeE. I. Du Pont de Nemours and Company
InventorRichard M. Scribner
Life of this patent
Estimating the term…
Abstract
Optically active tert-alkyl 7-2(oxo-5-carbonyloxypyrrolidinyl)heptanoates and their preparation by reaction of racemic tert-alkyl 7-(2-oxo-5-carboxypyrrolidinyl)heptanoate with an optically active amine to form resolved d or l amine salts which are then reacted with acid to form resolved acid intermediates. Esterification of these acid intermediates produces resolved d or l esters which are useful to make optically active 8-azaprostanoids having biological activity.
Claims6
A compound of the formula ##STR35## wherein the asterisk means that one enantiomer is predominant;
- A is CH.sub.2 CH.sub.2, CH.dbd.CH (cis or trans);
- or C.tbd.C;
- tAlk is a tertiary alkyl of 4 to 7 carbons;
- and R is a protonated optically-active amine selected from the group consisting essentially of (-)brucine, (-)cinchonidine, (+)dehydroabietylamine, (+).alpha.-(1-naphthyl)ethylamine, (-).alpha.-(1-naphthyl)ethylamine, (+)ephedrine, (-)ephedrine, (+).alpha.-methylbenzylamine, (-).alpha.-methylbenzylamine, (+)2-aminobutane, and (-)2-aminobutane.
1 more element
Dependencies are inferred from the claim text.