Antiarrhythmic phenethylpiperidine compounds
AssigneeMead Johnson & Company
InventorJohn E. Lawson
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Abstract
2-Phenethylpiperidines bearing urea, thiourea, and amidine substituents in the ortho-position of the phenethyl moiety have been synthesized and demonstrate useful antiarrhythmic properties. These novel compounds are prepared by reaction of appropriately substituted o-amino-phenethylpiperidines with appropriately substituted phenyl isothiocyanates, phenyl isocyanates, or phenyl imino esters.
Claims2
A compound selected from the group consisting of a compound having Formula (I) ##STR23## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, halogen, lower (meaning 1 to 4 carbon atoms inclusive) alkyl, lower alkoxy or lower alkylthio;
- R.sup.2 is hydrogen, hydroxy or methoxy;
- R.sup.3 and R.sup.4 are independently selected from hydrogen or lower alkyl;
- X is the divalent group ##STR24##
Dependencies are inferred from the claim text.