5,6-Dihydro-11-alkylene-morphanthridin-6-ones, their pharmaceutical compositions and method of use
AssigneeBASF SE
InventorsGerd Steiner, Ludwig Friedrich, Dieter Lenke
Life of this patent
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Abstract
Novel 5,6-dihydro-11-alkylene-morphanthridin-6-ones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description, their preparation and their use. The novel compounds are particularly useful in the treatment of gastric and duodenal ulcers.
Claims6
A 5,6-dihydro-11-alkylene-morphanthridin-6-one of the formula I ##STR9## where R.sup.1 and R.sup.2 are hydrogen, chlorine or methyl and R.sup.3 and R.sup.4 together with nitrogen atom by which they are linked form a piperazine ring in which the carbon atoms are unsubstituted or substituted by one or more alkyl radicals of 1 to 3 carbon atoms and the nitrogen atom is substituted by alkyl of 1 to 3 carbon atoms, hydroxylalkyl of 2 or 3 carbon atoms or phenyl which is itself unsubstituted or substituted by fluorine, chlorine, methoxy or methyl, or is in the form of the N-oxide, and/or its physiologically tolerated acid addition salts.
11-(4-Methylpiperazinyl-1-yl)-carboxamidomethylene-5,6-dihydromorphanthr idin-6one.
cis-11- (4-Methylpiperazinyl-1-yl)-carboxamidomethylene-5,6-dihydromorphanthridin-6 -one.
Dependencies are inferred from the claim text.