Pyrroloquinoline and benzoquinolizine compounds and antimicrobial compositions
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsHiroshi Ishikawa, Testuyuki Uno, Masanobu Kano, Kazuyuki Nakagawa
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Abstract
A benzoheterocyclic compound of the formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and n are as defined, and its pharmaceutically acceptable salts, processes for preparing same and antibacterial composition containing the benzoheterocyclic compound as an active ingredient and a pharmaceutically acceptable carrier are disclosed.
Claims23
A benzoheterocyclic compound of the formula (I) ##STR15## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group;
- R.sup.2 represents a hydrogen atom or a halogen atom;
- R.sup.3 represents a 1-pyrrolidinyl group which may be substituted with a hydroxymethyl group, a 1,2,5,6-tetrahydro-1-pyridyl group, or a group of the formula ##STR16## where R.sup.4 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group, a phenyl-lower alkyl group, a lower alkanoyloxy group, an amino group which may be substituted with a lower alkyl group or a lower alkanoyl group, an oxo group, or a carbamoyl group;
- Z represents an oxygen atom, a sulfur atom or a methylene group;
- and m is 1 or 2;
- and n is an integer of 1 or 2;
- or its pharmaceutically acceptable salt.
An antibacterial composition comprising an antibacterially effective amount of a benzoheterocyclic compound of the formula (I) ##STR20## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group;
- R.sup.2 represents a hydrogen atom or a halogen atom;
- R.sup.3 represents a 1-pyrrolidinyl group which may be substituted with a hydroxymethyl group, a 1,2,5,6-tetrahydro-1-pyridyl group, or a group of the formula ##STR21## where R.sup.4 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group, a phenyl-lower alkyl group, a lower alkanoyloxy group, an amino group which may be substituted with a lower alkyl group or a lower alkanoyl group, an oxo group, or a carbamoyl group;
- Z represents an oxygen atom, a sulfur atom or a methylene group;
- and m is 1 or 2;
- and n is an integer of 1 or 2;
- or its pharmaceutically acceptable salt, as an active ingredient and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.