7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)-aceta mido]-3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C.sub.1 -C.sub.6 alkyl derivatives thereof
AssigneeAmerican Cyanamid Company
InventorsWilliam V. Curran, Adma S. Ross
Life of this patent
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Abstract
7-Beta-[alpha-syn-methoxyimino-alpha-(2-aminothiazol-4-yl)acetamido]-3-[(1, 2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid and C.sub.1 -C.sub.6 alkyl derivatives thereof, useful as antibacterial agents.
Claims9
A compound selected from those of the formula:
- ##STR6## wherein R is selected from the group consisting of hydrogen and R.sub.1, wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl;
- and the pharmaceutically acceptable nontoxic cation salts thereof.
The compound of claim 1, 7.beta.-[.alpha.-syn-methoxyimino-.alpha.-(2-aminothiazol-4-yl)acetamido]- 3-[(1,2,3-thiadiazol-5-ylthio)methyl]-3-cephem-4-carboxylic acid.
The compound of claim 1, 7.beta.-[.alpha.-syn-methoxyimino-.alpha.-(2-aminothiazol-4-yl)acetamido]- 3-[(1,2,3-thiadiazol-4-methyl-5-ylthio)methyl]-3-cephem-4-carboxylic acid.
A method for treating bacterial infections in warm-blooded animals which comprises administering to said animals an effective amount of a compound selected from those of the formula:
- ##STR7## wherein R is selected from the group consisting of hydrogen and R.sub.1, wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl;
- and the pharmaceutically acceptable nontoxic cationic salts thereof.
A composition of matter which comprises an effective amount of a compound of the formula:
- ##STR8## wherein R is selected from the group consisting of hydrogen and R.sub.1 wherein R.sub.1 and C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable nontoxic cationic salts thereof, in association with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.