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US 4,399,127 AGranted
Injectable oxytetracycline compositions
AssigneeDiamond Shamrock Corporation
InventorsWalter Hacke, Herman Horn
Life of this patent
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Abstract
Increased antibiotic content of oxytetracycline injectable compositions containing glycerol formal as the solvent is achieved by utilization of particular magnesium compounds, viz., magnesium oxide, magnesium hydroxide, magnesium carbonate, magnesium acetate and magnesium chloride. Magnesium chloride is utilized with oxytetracycline base only.
Claims9
A stable, injectable antibiotic composition of increased antibiotic concentration for parenteral administration comprising:
- (a) from about 15 to about 35 parts by weight of an antibiotic selected from the group consisting of oxytetracycline base and an acid addition salt thereof,
- (b) a magnesium compound selected from the group consisting of magnesium oxide, magnesium hydroxide and magnesium carbonate present in a molar ratio from about 0.8 to about 1.2 moles per mole of said antibiotic,
- (c) from about 50 to about 95 parts by weight of glycerol formal selected from the group consisting of 4-hydroxymethyl-1,3-dioxolane, 5-hydroxy-1,3-dioxane and mixtures thereof,
- (d) from about 10 to about 45 parts by weight of water,
- (e) an antioxidant in an amount sufficient to stabilize said composition, and
- (f) a buffering agent in an amount sufficient to provide a pH of from about 6 to about 9.5 in said composition.
3 more elements
Dependencies are inferred from the claim text.