Peptides having immunostimulating properties and pharmaceutical compositions containing them
AssigneeInstitut Pasteur
InventorRobert M. Fauve
Life of this patent
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Abstract
Peptides having immunostimulating properties making them applicable to pharmaceutical compositions for the treatment or prevention of infections. They contain the sequence prolyl glycyl.
Claims26
A method of stimulating macrophages in vivo in a host which comprises administering to said host an immunostimulant effective amount of a biologically active composition which comprises a biologically acceptable carrier and a peptide which is effective for stimulating macrophages in vivo having a prolyl.fwdarw.prolyl.fwdarw.glycyl sequence and a maximum of seven aminoacyl residues.
An immunostimulant peptide which peptide has not more than seven amino acid residues, which peptide has the following amino acid sequence:
- X.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwdarw.Y, wherein X is an amino acid residue selected from the group consisting of lysyl and histidyl, and Y is at least one amino acid residue selected from the amino acids consisting of proline and serine, but both residues not being the same, or hydroxyl.
A composition for stimulating an immune response in a host which comprises a biologically acceptable carrier and an immunostimulant effective amount of a pharmacologically active peptide, said peptide having a maximum of seven amino acid residues, which peptide has the following acid sequence:
- x.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwdarw.Y, wherein X is an amino acid residue selected from the group consisting of lysyl and histidyl, and Y is at least one amino acid residue selected from the amino acids consisting of proline and serine but both residues not being the same, or hydroxyl.
A method for stimulating an immunal response in a host which comprises a administering biologically acceptable carrier and an immunostimulant effective amount of a pharmacologically active peptide, said peptide having a maximum of seven amino acid residues, which peptide has the following acid sequence:
- X.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwdarw.Y, wherein X is an amino acid residue selected from the group consisting of lysyl and histidyl, and Y is at least one amino acid residue selected from the amino acids consisting of proline and serine, but both residues not being the same, or hydroxyl.
A method of stimulating macrophages in vivo in a host which comprises administering to said host an immunostimulant effective amount of a biologically active composition which comprises a biologically acceptable carrier and a hexa or hepta peptide selected from the group consisting of:
- lysyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwdarw .serine;
- lysyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwdarw .seryl.fwdarw.proline;
- Histidyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwd arw.serine;
- Histidyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwd arw.seryl.fwdarw.proline;
- arginyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwda rw.serine;
- and arginyl.fwdarw.prolyl.fwdarw.prolyl.fwdarw.glycyl.fwdarw.phenylalanyl.fwda rw.seryl.fwdarw.proline.
Dependencies are inferred from the claim text.