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US 4,399,121 AGranted
Iodothyronine immunogens and antibodies
AssigneeMiles Laboratories, Inc.
InventorsJames P. Albarella, Robert J. Carrico, Thomas M. Li
Life of this patent
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Abstract
Immunogen conjugates comprising N-aminoalkyl derivatives of iodothyronines, e.g., thyroxine and its lower alkyl esters, coupled to an immunogenic carrier material, and antibodies raised against such immunogen conjugates.
Claims23
An iodothyronine immunogen conjugate of the formula:
- ##STR6## wherein Carrier is an immunogenic carrier material, R' is a bond or a linking group, n is an integer from 2 through 12, p is on the average from 1 through about 50, R is hydrogen or alkyl containing 1-6 carbon atoms, and .beta..sup.1 and .beta..sup.2 are, independently, hydrogen or iodine.
An iodothyronine immunogen conjugate of the formula:
- ##STR8## wherein Carrier (CO)--represents an immunogenic protein or polypeptide carrier material bound through a carboxyl group, n is an integer from 2 through 12, p is on the average from 1 through the number of available carboxyl groups on said carrier material, R is hydrogen or alkyl containing 1-6 carbon atoms, and .beta..sup.1 and .beta..sup.2 are, indpendently, hydrogen or iodine.
Dependencies are inferred from the claim text.