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US 4,398,028 AGranted
Bicyclic heterocyclic amino derivatives
AssigneeSandoz Ltd.
InventorPeter Neumann
Life of this patent
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Abstract
The present invention concerns compounds of formula ##STR1## wherein X is O, S or NH; n is 1 or 2 and A is a 5-membered heterocyclic ring, wherein the bicyclic system may be substituted. The compounds are useful as myotonolytic and anti-hypertensive agents.
Claims33
A compound having the formula ##STR6## wherein the heterocyclic amino moiety is bonded to the benzene ring of the bicyclic moiety,
- n is an integer 1 or 2,
- R.sub.1, which is bonded to the benzene ring of the bicyclic moiety, is hydrogen, halo, C.sub.1-4 -alkyl, C.sub.1-4 alkylthio, C.sub.1-4 alkoxy, trifluoromethyl or hydroxy,
- A is a five-membered heterocyclic ring selected from the group consisting of [b]pyrrole, [c]pyrrole, [d]triazole, [b]furan, [c]furan, [c]furazan, [d](1,2,3)-thiadiazole, [b]pyrroline, [c]pyrroline, [b]dihydrofuran, [c]dihydrofuran, [b]dihydrothiophene, [c]isoxazole and [d]isoxazole,
- R.sub.2, which is bonded to the A ring of the bicyclic moiety and attached to a carbon atom of said ring, is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, trifluoromethyl or hydroxy, and
- R.sub.3, which is bonded to the A ring of the bicyclic moiety and attached to a nitrogen atom of said ring, is hydrogen or C.sub.1-4 alkyl, with the proviso that when A is [c]pyrrole, the nitrogen atom of said pyrrole ring is C.sub.1-4 alkylsubstituted,
- said compound being in free base or in pharmaceutically acceptable acid addition salt form.
3 more elements
Dependencies are inferred from the claim text.