Polymeric anti-tumor agent and method of preparation
AssigneeMonsanto Company
InventorsMarvin L. Oftedahl, Howard M. Solomon, James A. Webster
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Abstract
An improved pharmaceutically active derivative of a copolymer of olefin monomer and .alpha.,.beta.-unsaturated polycarboxylic anhydride is prepared by reacting the copolymer with aqueous ammonia, spray drying the resulting aqueous solution of half-amide, half-ammonium salt and thermally imidating the resulting substantially dry, solid particulate product by simultaneous treatment with elevated temperature and removal of water until 5-40% of the derivative half-amide, half-ammonium salt groups are converted to imide groups.
Claims7
The method of making an improved pharmaceutically active derivative of a copolymer of an olefin monomer having from 2 to about 4 carbon atoms and an .alpha.,.beta.-unsaturated polycarboxylic anhydride having from 4 to about 6 carbon atoms, said copolymer having a number average molecular weight of from about 300 to about 1500, comprising reaction said copolymer with aqueous ammonia in an amount sufficient to form an aqueous solution of a copolymer derivative having half-amide, half-ammonium salt groups, spray drying said aqueous solution to provide a substantially dry particulate solid form of said copolymer derivative, and then thermally imidating said substantially dry copolymer derivative by simultaneous treatment with elevated temperature and removal of water until from about 5% to about 40% by weight of said derivative groups are converted to imide groups.
Dependencies are inferred from the claim text.