Method of treating atherosclerosis with trisubstituted ureas

A method of treating atherosclerosis, reducing the cholesterol ester content of the arterial wall, inhibiting atherosclerotic lesion development and/or treating hyperlipidemia in a mammal in need of such treatment which comprises administering to said mammal an effective amount of a compound of the formula:

• ##STR5## wherein R.sub.1 and R.sub.2 are different and are independently selected from the group consisting of C.sub.4 -C.sub.12 alkyl, C.sub.4 -C.sub.12 alkenyl, C.sub.4 -C.sub.12 alkynyl, C.sub.4 -C.sub.12 cycloalkyl, C.sub.4 -C.sub.12 cycloalkylalkyl, C.sub.7 -C.sub.14 aralkyl, and C.sub.7 -C.sub.14 aralkyl in which an aromatic ring bears at least one substituent selected from the group consisting of C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkoxy, phenoxy, benzyloxy, methylenedioxy, C.sub.1 -C.sub.4 alkylthio, phenyl, halo, trihalomethyl, adamantyl, C.sub.1 -C.sub.4 carboalkoxy, and nitro.