Back to results
US 4,397,862 AGranted
Gastrointestinal sparing thioester drugs
AssigneeSyntex (U.S.A.) Inc.
InventorsEdward Mroszczak, Richard Runkel
Life of this patent
Estimating the term…
Abstract
Compounds of the formula: R'--CH.sub.2 --S--A wherein: R' is hydrogen, alkyl, --COOH or its pharmaceutically acceptable salts, --alkylene--COOH or its pharmaceutically acceptable salts, --alkylene-SO.sub.2 H or its pharmaceutically acceptable salts, --alkylene-SO.sub.3 H or its pharmaceutically acceptable salts, or --alkylene CH.sub.2 OH; and A is the acyl moiety of a pharmaceutically acceptable carboxylic acid, said acid having antiinflammatory properties; are gastrointestinal tract sparing drugs for antiinflammatory pharmaceuticals.
Claims6
A compound of the formula:
- R'--CH.sub.2 --S--A
- wherein
- R' is hydrogen, alkyl, -COOH or its pharmaceutically acceptable salts, --alkylene-COOH or its pharmaceutically acceptable salts, --alkylene-SO.sub.2 H or its pharmaceutically acceptable salts, --alkylene-SO.sub.3 H or its pharmaceutically acceptable salts, or --alkylene-CH.sub.2 OH;
- and
- A is the acyl moiety of a pharmaceutically acceptable carboxcylic acid of the formula:
- ##STR4## wherein R.sup.3 is hydrogen, halo, or lower alkyl;
- and Ar is selected from the group consisting of:
- ##STR5## in which X is O or S;
- R is hydrogen, methyl, chloro or bromo;
- R.sup.1 is hydrogen, a lower alkyl group having 1 to 4 carbon atoms;
- a lower alkoxy group having from 1 to 4 carbon atoms, chloro, fluoro or bromo;
- and
- R.sup.2 is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms.
10 more elements
Dependencies are inferred from the claim text.