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US 4,397,855 AGranted
4-(Substituted)-.alpha., .alpha.-dimethyl-1-piperazine pentanoic acids and derivatives as anti-arteriosclerotic agents and method
AssigneeWarner-Lambert Company
InventorIla Sircar
Life of this patent
Estimating the term…
Abstract
New 4-(substituted-.alpha., .alpha.-dimethyl-1-piperazine pentanoic acids and derivatives which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.
Claims17
A compound having the structural formula ##STR15## wherein R and R.sub.1 may be the same or different and are hydrogen, halogen, alkyl of from 1 to 6 carbon atoms, trifluoro methyl, carboxylic acid of from 1 to 3 carbon atoms, or 1-hydroxyalkyl of from 1 to 3 carbon atoms;
- R.sub.2 is hydrogen, alkyl of from 1 to 3 carbon atoms, or a pharmaceutically acceptable cation;
- A is a direct bond, methylene, benzal, CH.dbd.CH--CO, and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.