Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
AssigneeWarner-Lambert Company
InventorIla Sircar
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Abstract
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents. Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted .gamma.-oxobenzenebutanoic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product. The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.
Claims5
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form in a pharmaceutically acceptable carrier to such patient an effective amount of a compound having the structural formula ##STR5## wherein represents a double or single bond between two carbon atoms;
- R is hydrogen, lower alkyl, dialkylaminoalkyl or hydroxyalkyl;
- R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl or phenylmethyl with the proviso that at least one of them is hydrogen;
- Y and Z are independently hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, phenoxy, CN or NR.sub.3 R.sub.4 wherein R.sub.3 is hydrogen or lower alkyl and R.sub.4 is hydrogen, lower alkyl or ##STR6## wherein R.sub.5 is hydrogen or alkyl containing one or two carbon atoms;
- wherein lower alkyl and lower alkoxy contain one to three carbon atoms;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.