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US 4,397,845 AGranted
Lincomycin 3-(5'-adenylate) as anesthetic
AssigneeThe Upjohn Company
InventorHarry R. Allen
Life of this patent
Estimating the term…
Abstract
The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used as a local anesthetic in humans and animals.
Claims3
A method for treating a human or animal subject in need of a local anesthetic which comprises administering to said subject an effective local anesthetic dose of a compound of the formula
- R.sub.1 is H, C.sub.1 -C.sub.8 -alkyl;
- R.sub.11 is OH, OCH.sub.3, halogen (Cl, Br, I), --SCH.sub.2 CH.sub.2 OH, --SCH.sub.2 CH.sub.2 CH.sub.2 OH, SCH.sub.3 ;
- R.sub.12 is CH.sub.3, CH.sub.2 CH.sub.3, --CH.sub.2 CH.sub.2 OH, ##STR3## or the pharmaceutically acceptable acid addition salts thereof, selected from the group consisting of hydrochloride, sulfate, phosphoric, sodium, potassium, calcium, and lithium, as an essential active ingredient in combination with a pharmaceutical carrier.
Dependencies are inferred from the claim text.