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US 4,397,784 AGranted
Inhibitors of transpeptidase
AssigneeAbbott Laboratories
InventorDaniel T. Chu
Life of this patent
Estimating the term…
Abstract
New .beta.-lactams of the general structure: ##STR1## wherein X=O or S; R represents H, loweralkyl, acyl, aryl, or arylloweralkyl; R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto; R" is hydrogen or loweralkyl; and the broken line represents an optional double bond, and certain esters thereof. All compounds are effective antibacterials.
Claims6
A compound of the formula ##STR6## wherein X=O or S;
- R represents H, loweralkyl, phenacetyl, phenoxyacetyl, cyanoacetyl, thenylacetyl, p-sulfophenacetyl, N-benzoylglycylphenylglycyl, a moiety of the formula ##STR7## wherein Y is O or NOR", a mercaptoacetyl of the formula R.degree.SCH.sub.2 CO- wherein R.degree. is phenyl, 4-pyridyl, 2-chloro-2-butenyl, allyl or n-butyl, phenyl, phenylloweralkyl, substituted phenyl or substituted phenylloweralkyl, wherein substituted phenyl is a phenyl moiety substituted with one or more groups independently selected from hydroxy, loweralkoxy, amino, nitro, halo, loweralkyl or phenylloweralkyl;
- R' is hydrogen, loweralkoxy, loweralkoxyalkyl, loweralkyl, phenylthio or loweralkylmercapto;
- R" is hydrogen or loweralkyl;
- and the broken line represents an optional double bond, and acyloxymethyl esters thereof.
1 more element
Dependencies are inferred from the claim text.