Antiinflammatory 17-spiroandrostenes
AssigneeE. R. Squibb & Sons, Inc.
InventorRavi K. Varma
Life of this patent
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Abstract
Topical antiinflammatory activity is exhibited by steroids having the formula ##STR1## and the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, alkyl, carboxyl, or alkoxycarbonyl; R.sub.2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a conventional hydrolyzable ester thereof, methoxy, or oxo (.dbd.O); R.sub.3 is carbonyl or .beta.-hydroxymethylene; R.sub.4 is hydrogen or fluorine; R.sub.5 is hydrogen, methyl or fluorine; X and Y are the same or different, and each is S, O, NH, N--CH.sub.3, SO or SO.sub.2 ; and n is 1, 2, 3, 4 or 5.
Claims22
A steroid having the formula ##STR15## or the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, alkyl, carboxyl, or alkoxycarbonyl;
- R.sub.2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a conventional hydrolyzable ester thereof, methoxy, or oxo;
- R.sub.3 is carbonyl or .beta.-hydroxymethylene;
- R.sub.4 is hydrogen or fluorine;
- R.sub.5 is hydrogen, methyl or fluorine;
- X and Y are the same or different, and each is S, O, NH, N--CH.sub.3, SO or SO.sub.2 ;
- and
- n is 1, 2, 3, 4 or 5;
- with the proviso that X and Y are not both O.
A steroid having the formula ##STR16## or the 1,2-dehydro and 15,16-dehydro derivatives thereof, wherein R.sub.1 is hydrogen, alkyl, carboxyl, or alkoxycarbonyl;
- R.sub.2 is hydrogen, chlorine, bromine, fluorine, methyl, hydroxyl or a conventional hydrolyzable ester thereof, methoxy, or oxo;
- R.sub.3 is carbonyl or .beta.-hydroxymethylene;
- R.sub.5 is hydrogen, methyl or fluorine;
- n is 1, 2, 3, 4 or 5.
Dependencies are inferred from the claim text.