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US 4,396,629 AGranted
Compositions, processes and method
AssigneeSterling Drug Inc.
InventorRichard E. Philion
Life of this patent
Estimating the term…
Abstract
Therapeutically useful 1-(substituted-amino)-3-[4-R.sub.1 O-3-(lower-alkylthio, lower-alkylsulfinyl or lower-alkylsulfonyl)phenoxy]-2-propanols are obtained by reacting a 4-R.sub.1 0-3-(lower-alkylthio, lower-alkylsulfinyl or lower-alkylsulfonyl)phenol with an epihalohydrin and reacting the resulting product with a primary amine. The compounds have both antihypertensive and .beta.-adrenergic blocking activity and are useful as antihypertensive agents.
Claims31
A compound having the formula ##STR20## wherein:
- Y is lower-alkylthio, lower-alkylsulfinyl or lower-alkylsulfonyl;
- R.sub.1 is hydrogen, lower-alkyl or benzyl;
- R.sub.2 is lower-alkyl or ##STR21## R.sub.3 and R.sub.4 are independently hydrogen or lower-alkyl;
- Q is hydrogen, lower-alkyl, hydroxy or lower-alkoxy;
- and
- n is 1, 2 or 3;
- or an acid-addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.