Cyclic compounds and their use
AssigneeBeecham Group Limited
InventorsRobert W. Ward, Alexander C. Goudie
Life of this patent
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Abstract
Compounds of the formula (I): ##STR1## and pharmaceutically acceptable salts and pro-drugs thereof, wherein: Ar is a phenyl group optionally substituted by one or two moieties selected from halogen, C.sub.1-4 alkyl, methoxy, methylthio or trifluoromethyl, or a 2-thienyl group or N-methyl-2-pyrryl group optionally substituted by one or two C.sub.1-4 alkyl groups; R is hydrogen or methyl; and n is 0 or 1 having useful anti-inflammatory and/or analgesic activity, pharmaceutical compositions containing them, and processes for their preparation.
Claims6
A compound of the formula (I):
- ##STR27## or a pharmaceutically acceptable salt or a pro-drug thereof, wherein:
- Ar is phenyl unsubstituted or substituted by one or two moieties selected from halogen, C.sub.1-4 alkyl, methoxy, methylthio or trifluoromethyl;
- R is hydrogen or methyl;
- and
- n is 0 or 1.
5-p-Chlorobenzoyl-1-methyl-4-trifluoromethylpyrrole-2-acetic acid,
- 5-(3'-chlorobenzoyl)-1-methyl-4-trifluoromethylpyrrole-2-acetic acid,
- 5-(4'-methylbenzoyl)-1-methyl-4-trifluoromethylpyrrole acetic acid,
- 5-(4'-methoxybenzoyl)-1-methyl-4-trifluoromethylpyrrole acetic acid,
- 5-(3'-trifluoromethylbenzoyl)-1-methyl-4-trifluoromethylpyrrole acetic acid,
- 4-[5'-(4"-chlorobenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyrryl]but-1-ene,
- 4-[5'-(3"-chlorobenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyrryl]but-1-ene,
- 4-[5'-(4"-methylbenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyrryl]but-1-ene,
- 4-[5'-(4"-methoxybenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyrryl]but-1-ene,
- 4-[5'-(3"-trifluoromethylbenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyrryl]bu t-1-ene,
- 4-[5'-(4"-chlorobenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyroyl]butan-2-one
- 4-[5'-(3"-chlorobenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyroyl]butan-2-one
- 4-[5'-(4"-methylbenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyroyl]butan-2-one
- 4-[5'-(4"-methoxybenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyroyl]butan-2-on e,
- 4-[5'-(3"-trifluoromethylbenzoyl)-1'-methyl-4'-trifluoromethyl-2'-pyroyl]bu tan-2-one,
- ethyl 5-(4'-methylbenzoyl)-1-methyl-4-trifluoromethylpyrrole-2-acetate,
- ethyl 5-(4'-methoxybenzoyl)-1-methyl-4-trifluoromethylpyrrole-2-acetate or
- ethyl 5-(3'-trifluoromethylbenzoyl)-1-methyl-4-trifluoromethylpyrrole-2-acetate
Dependencies are inferred from the claim text.