Carbocyclic analogs of uracil nucleosides as antiviral agents
AssigneeSouthern Research Institute
InventorsY. Fulmer Shealy, C. Allen O'Dell, William M. Shannon
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Abstract
There is provided a method for the treatment of viral infections by treating a host animal with a pharmaceutically effective amount of a carbocyclic analog of a nucleoside represented by Formula I: ##STR1## wherein X is chlorine, bromine, iodine, a lower alkyl group or an amino group of the formula --NHR.sup.2 wherein R.sup.2 is a lower alkyl group; and R and R' can be the same or different members selected from the group consisting of hydrogen, an alkanoyl group or an aroyl group.
Claims16
A process for the treatment of a host animal having a herpes virus infection which comprises administering to said host animal a therapeutically effective amount of a compound represented by the following formula:
- ##STR4## wherein X is bromine, iodine, methyl or an amino group of the formula --NHR.sup.2 wherein R.sup.2 is a C.sub.1-4 lower alkyl group;
- and R and R.sup.1 can be the same or different members selected from the group consisting of hydrogen or a C.sub.1-6 alkanoyl group.
A compound having the formula:
- ##STR5## wherein R.sup.2 is a C.sub.1-4 lower alkyl group, and R and R.sup.1 can be the same or different members selected from the group consisting of hydrogen or a C.sub.1-6 alkanoyl group.
(.+-.)-5-Bromo-1-[(1.alpha.,3.b eta.,4.alpha.)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]-2,4(1H,3H)-pyrimidin edione diacetate.
(.+-.)-1-[(1. alpha.,3.beta.,4.alpha.)-3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-5-iodo-2,4 (1H,3H)-pyrimidinedione diacetate.
Dependencies are inferred from the claim text.