Certain 2-oxo-2,3-dihydro-3-benzothiophene-carboxamides and their pharmaceutical compositions
AssigneeCiba-Geigy Corporation
InventorsRaymond Bernasconi, Pier G. Ferrini, Richard Goschke, Jacques Gosteli
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Abstract
Oxothia compounds, especially 2-oxo-2,3-dihydro-benzo[b]-thiophene compounds of the formula ##STR1## in which Ph represents an optionally substituted 1,2-phenylene radical, X represents oxygen or sulphur, R.sub.1 represents an organic radical bonded via a carbon atom and R.sub.2 denotes hydrogen or an optionally substituted hydrocarbon radical of aliphatic character, and their salts are useful as peripheral analgetics and/or as antiphlogistic uricosuric and/or thrombolytic agents.
Claims10
An compound of the formula ##STR10## in which Ph represents 1,2-phenylene which is optionally substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, X represents oxygen or sulphur, R.sub.1 represents pyridinyl or 6-membered di-azaaryl which radicals are optionally substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro, or furyl, thienyl, a 5-membered oxaza- or thiaza-aryl which radicals are optionally substituted by lower alkyl, lower alkoxy, halogen, trifluoromethyl and/or nitro and R.sub.2 represents hydrogen or lower alkyl, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.