Cephalosporin quinolinium betaines
AssigneeEli Lilly and Company
InventorWilliam H. W. Lunn
Life of this patent
Estimating the term…
Abstract
Broad spectrum cephalosporin antibiotics represented by the formula ##STR1## wherein R' is a heterocyclic, eg. 2-aminothizol-4-yl or 5-amino-1,2,4-thiadiazol-3-yl; R" is C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl or cycloalkyl group, or an N-substituted carbamoyl group; and R.sub.1 and R.sub.2 represent substituent groups, eg. amino, hydroxy, halogen, carboxy, carbamoyl, alkyl, alkylamino, sulfo, and sulfonamido; and formulations of the antibiotics are provided. The antibiotics are useful in a method for treating bacterial infections.
Claims19
A compound of the formula ##STR21## wherein R is formyl, or an acyl group of the formula ##STR22## wherein R' is a 5- or 6-membered heterocyclic ring of the formulas ##STR23## R" is C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl, or carboxy-substituted cycloalkyl group of the formula ##STR24## wherein n is 0-3, a and b when taken separately are independently hydrogen or C.sub.1 -C.sub.3 alkyl, or when taken together with the carbon to which they are attached form a C.sub.3 -C.sub.7 carbocyclic ring;
- R'" is hydroxy, C.sub.1 -C.sub.4 alkoxy, amino, and when R'" is hydroxy a carboxy-protecting group;
- R.sub.1 and R.sub.2 independently are hydrogen, amino, C.sub.1 -C.sub.4 alkylamino, di-(C.sub.1 -C.sub.4 alkyl)amino, or hydroxy;
- provided that one of R.sub.1 or R.sub.2 is other than hydrogen;
- and the pharmaceutically acceptable, non-toxic salts thereof.
Dependencies are inferred from the claim text.