Bis-thymosine .alpha.-1 compounds
AssigneeMax-Planck-Gesellschaft zur Forderung der Wissenschaften e.V.
InventorChristian Birr
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Abstract
Bis-thymosine .alpha.-1 consisting of two desacetylthymosine .alpha.-1 un N-terminally linked by a bridge bond of 1 to 10 carbon atoms, especially an .alpha.,.omega.-diacyl residue with 2 to 10 carbon atoms. This new compound is made by converting a synthetic desacetylthymosine .alpha.-1 in which all functional groups of amino acids 1 through 28, except the N-terminal group, are blocked by protective groups conventional in peptide synthesis with a coupling compound of 1 to 10 carbon atoms and that reacts with NH.sub.2 groups, in a polar solvent, and then removing the protective groups.
Claims16
Bis-thymosine.alpha.-1 compound of the formula
- T.sub.2 R
- in which
- T is a desacetylthymosine.alpha.-1 residue,
- R is a .alpha.,.omega.-diacyl residue of 2 to 10 carbon atoms, optionally containing at least one of an aromatic nucleus, OH-groups, NH.sub.2 -groups, halogen atoms, and olefinic double bonds, or where R is a CO-group.
Succinyl-bis-desacetylthymosine.alpha.-1.
Dependencies are inferred from the claim text.