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US 4,396,603 AGranted
Novel antibiotic SF-2107 series substance and process for preparing the same
AssigneeMeiji Seika Kaisha, Ltd.
InventorsNorio Ezaki, Takashi Shomura, Shoichi Amano, Tomizo Niwa, Michio Kojima, Tatsuo Ito
Life of this patent
Estimating the term…
Abstract
Disclosed is a novel antibiotic SF-2107 series substance consisting essentially of Substance SF-2107 A-1, Substance SF-2107 B and/or Substance SF-2107 C, each having the phisico-chemical properties as described in the specification, which substance exhibits an antibacterial activity against both gram-positive and gram-negative bacteria and is useful for pharmaceuticals, bactericides, disinfectants, etc. Also disclosed is a process for preparing the substance.
Claims7
An antibiotic Substance SF-2107 A-1 having the following physico-chemical properties:
- Elementary analysis:
- C, 58.39 wt %;
- H, 7.88 wt %;
- O, 33.73 wt % (balance) which does not contain any nitrogen, halogen, sulfur, phosphorus
- Molecular weight:
- 900-1100 (gel filtration method)
- Melting point:
- 170 .degree.-184.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.25 +20.degree. (c=0.2, Methanol)
- Ultraviolet absorption spectrum:
- Absorption maxima at 250 nm (E.sub.1 cm.sup.1% =72), 342 nm (206), (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3460, 2950, 1730, 1630, 1610, 1460, 1380, 1300, 1280, 1130, 1100, 1040, 910, 860, 820, 790, 750, 740, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Pale yellow powder Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.67 (chloroform:methanol=5:1)=0.56 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water
20 more elements
An antibiotic Substance SF-2107 B having the following physico-chemical properties:
- Elementary analysis:
- C, 53.66 wt %;
- H, 6.75 wt %;
- O, 39.59 wt % (balance) which does not contain any nitrogen, sulfur, phosphorus, or halogen
- Molecular weight:
- 900-1100 (gel filtration method)
- Melting point:
- 170.degree.-175.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.23 =-5.degree. (c=1, Methanol)
- Ultraviolet absorption spectrum:
- Absorption maxima at 242 nm (E.sub.1 cm.sup.1% =52), 343 (206), (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3450, 2970, 2930, 1720, 1600, 1440, 1370, 1270, 1170, 1130, 1040, 980, 790, 750, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Slightly yellowish powder
- Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.34 (chloroform:methanol=5:1)=0.51 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water
21 more elements
An antibiotic Substance SF-2107 C having the following physico-chemical properties:
- Elementary analysis:
- C, 57.50 wt %;
- H, 7.04 wt %;
- O, 34.46 wt % (balance) which does not contain any nitrogen, sulfur, phosphorus, or halogen
- Molecular weight:
- 900-1100 (gel filtration method)
- Melting point:
- 155.degree.-168.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.23 =+29.8.degree. (c=1, methanol)
- Ultraviolet absorption spectrum:
- Absorption maximum at 345 nm (E.sub.1 cm.sup.1% =258) (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3430, 2930, 1720, 1620, 1600, 1440, 1370, 1300, 1270, 1130, 1100, 1050, 900, 790, 750, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Slightly yellowish powder
- Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.27 (chloroform:methanol=5:1)=0.07 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water
21 more elements
An antibacterial composition which comprises as an active ingredient, an antibacterially effective amount of Substance SF-2107 A-1 having the following physico-chemical properties:
- Elementary analysis:
- C, 58.39 wt %, H, 7.88 wt %;
- O, 33.73 wt % (balance) which does not contain any nitrogen, sulfur, phosphorus, or halogen
- Molecular weight:
- 900-1100 (gel filtration method)
- Melting point:
- 170.degree.-184.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.25 =+20.degree. (c=0.2, Methanol)
- Ultraviolet absorption spectrum:
- Absorption maxima at 250 nm (E.sub.1 cm.sup.1% =72), 342 nm (206), (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3460, 2950, 1730, 1630, 1610, 1460, 1380, 1300, 1280, 1130, 1100, 1040, 910, 860, 820, 790, 750, 740, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Pale yellow powder
- Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.67 (chloroform:methanol=5:1)=0.56 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water, and a pharmaceutically acceptable carrier.
20 more elements
An antibacterial composition which comprises as an active ingredient, an antibacterially effective amount of Substance SF-2107 B having the following physico-chemical properties:
- Elementary analysis:
- C, 53.66 wt %;
- H, 6.75 wt %;
- O, 39.59 wt % (balance) which does not contain any nitrogen, sulfur, phosphorus, or halogen
- Molecular weight:
- 900-1100 (gel filtration method) PG,29
- Melting point:
- 170.degree.-175.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.23 =-5.degree. (c=1, Methanol)
- Ultraviolet absorption spectrum:
- Absorption maxima at 242 nm (E.sub.1 cm.sup.1% =52), 343 (206), (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3450, 2970, 2930, 1720, 1600, 1440, 1370, 1270, 1170, 1130, 1040, 980, 790, 750, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Slightly yellowish powder
- Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.34 (chloroform:methanol=5:1)=0.51 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water, and a pharmaceutically acceptable carrier.
21 more elements
An antibacterial composition which comprises as an active ingredient, an antibacterially effective amount of Substance SF-2107 C having the following physico-chemical properties:
- Elementary analysis:
- C, 57.50 wt %;
- H, 7.04 wt %;
- O, 35.46 wt % (ballance) which does not contain any nitrogen, sulfur, phosphorus, or halogen
- Molecular weight:
- 900-1100 (gel filtration method)
- Melting point:
- 155.degree.-168.degree. C. (slowly molten)
- Specific rotation:
- [.alpha]sub.D.sup.23 =+29.8.degree. (c=1, methanol)
- Ultraviolet absorption spectrum:
- Absorption maximum at 345 nm (E.sub.1 cm.sup.1% =258) (in methanol)
- Infrared absorption spectrum:
- Characteristic absorption bands at 3430, 2930, 1720, 1620, 1600, 1440, 1370, 1300, 1270, 1130, 1100, 1050, 900, 790, 750, 690 cm.sup.-1 (KBr tablet method)
- Color reaction:
- Iodine reaction, Lemieux reaction, positive Ninhydrin reaction, ferric chloride reaction, negative
- State:
- Slightly yellowish powder
- Neutrality, acidity or basicity:
- Acting as a neutral or weakly acidic substance (electrophoresis)
- Silica gel thin-layer chromatography:
- Rf=0.27 (chloroform:methanol=5:1)=0.07 (acetone:benzene=5:1)
- Solubility:
- Soluble in methanol, acetone. Sparingly soluble in benzene, chloroform, n-hexane, water, and a pharmaceutically acceptable carrier.
21 more elements
Dependencies are inferred from the claim text.