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US 4,396,553 AGranted
Tetrahydronaphthalene and indane compounds useful as anti-tumor agents
AssigneeHoffmann-La Roche Inc.
InventorMichael Klaus
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Abstract
This invention is directed to tetrahydronaphthalene and indane compounds and processes thereto. These compounds are useful as tumor inhibiting agents, in the treatment of neoplasms and dermatological conditions.
Claims25
Compounds of the formula ##STR8## wherein n represents 1 or 2;
- Z represents mercapto or --S(O).sub.m R, wherein m represents 0, 1 or 2;
- R represents lower-alkyl, lower-alkenyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl or, when m is 1 or 2, R represents also lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylamino,
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.