Derivatives of A-21978C cyclic peptides

An A-21978C cyclic peptide derivative of the formula:

• ##STR74## wherein R is hydrogen, 8-methyldecanoyl, 10-methyldodecanoyl, 10-methylundecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C.sub.0 or the specific C.sub.12 -alkanoyl groups of A-21978C factors C.sub.4 and C.sub.5, an amino-protecting group, an aminoacyl group of the formula ##STR75## wherein Q is C.sub.1 -C.sub.16 alkylene, or an N-alkanoylamino acyl group of the formula ##STR76## wherein:
• W is a divalent aminoacyl radical of the formula:
• ##STR77## wherein A is C.sub.1 -C.sub.10 alkylene or C.sub.5 -C.sub.6 cycloalkylene;
• ##STR78## wherein R.sup.3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indole-methyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 -alkoxy, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl;
• ##STR79## wherein X is hydrogen chloro, bromo, iodo, amino, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, mercapto, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl;
• ##STR80## wherein X.sup.1 is chloro, bromo, iodo, amino, hydroxy, C.sub.1 -C.sub.3 alkyl or C.sub.1 -C.sub.3 alkoxy;
• ##STR81## wherein B is a divalent radical of the formula:
• --(CH.sub.2).sub.n -- and n is an integer from 1 to 3;
• --CH.dbd.CH--;
• --CH.dbd.CH--CH.sub.2 --;
• or ##STR82## R.sup.2 is C.sub.1 -C.sub.17 alkyl or C.sub.2 -C.sub.17 alkenyl;
• and R.sup.1 is hydrogen, an amino-protecting group, an aminoacyl group of the formula ##STR83## as herein defined, or an N-alkanoylaminoacyl group of the formula ##STR84## as herein defined;
• provided that, when R is other than aminoacyl or N-alkanoylaminoacyl, R.sup.1 must be aminoacyl or N-alkanoylaminoacyl;
• and, when R.sup.1 is an amino-protecting group, R must be aminoacyl or N-alkanoylaminoacyl;
• and the salts thereof.