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US 4,395,575 AGranted
5(Halophenyl)-2-fluoro-pentadienals
AssigneeHoffmann-La Roche Inc.
InventorsKa-Kong Chan, Beverly A. Pawson
Life of this patent
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Abstract
9-Substituted, 4- or 6-fluorine substituted retinoic acid derivatives useful as antitumor agents and in the treatment of acne as well as a method for their manufacture are disclosed. Substituents at the 9-position include substituted phenyl, thienyl and furyl groups.
Claims2
A compound of the formula:
- ##STR49## wherein R.sub.1 is fluorine;
- at least one of R.sub.4, R.sub.5 and R.sub.7 is halogen and the others are hydrogen or lower alkyl;
- and R.sub.6 is lower alkyl or lower alkoxy.
Dependencies are inferred from the claim text.