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US 4,395,419 AGranted
Pharmacologically active compounds
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham J. Durant, Charon R. Ganellin, Rodney C. Young
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Abstract
Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. A specific compound of this invention is N-[2-(3-(1,2,5)-thiadiazolylmethylthio)ethyl]amidinoformic acid.
Claims10
A compound of the formula ##STR6## wherein Het is a thiadiazole ring, which ring is optionally substituted by lower alkyl, halogen, lower alkoxy, hydroxy, trifluoromethyl, hydroxymethyl or amino;
- m is 0, 1 or 2 and n is 2 or 3 provided that the sum of m and n is 3 or 4;
- Y is sulphur, methylene or oxygen;
- R is hydrogen, lower alkyl or Het--(CH.sub.2).sub.m --Y--(CH.sub.2).sub.n -- where Het, m, n and Y are as defined above;
- Q is --CO.sub.2 H or --SO.sub.2 H;
- or a pharmaceutically acceptable acid addition salt thereof.
2 more elements
Dependencies are inferred from the claim text.