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US 4,395,417 AGranted
Antihyperlipidemic compositions
AssigneeResearch Corporation
InventorsIris Hall, George Cocolas, James M. Chapman, Jr.
Life of this patent
Estimating the term…
Abstract
The invention concerns cyclic imides, diones, reduced diones and analogs thereof which are useful as antihyperlipidemic agents to reduce serum cholesterol and trigylcerides.
Claims14
Antihyperlipidemic compositions comprising a pharmaceutically acceptable carrier and, as the principal active ingredient, a compound of the group represented by the formulas:
- ##STR2## wherein X is aryl, cycloalkyl, or cycloalkylene containing up to ten carbon atoms;
- Y is CH or N;
- Z is alkyl containing up to five carbon atoms, carboxyl, carboalkoxyl wherein the alkyl group contains up to four carbon atoms, acyl containing up to four carbon atoms, alkylene, aryl, aralkyl or aralhylene;
- n is 1 to 10;
- and further compounds wherein the group represented by X is replaced with at least one hydrogen on each of the carbon atoms adjacent the oxygen bearing functional groups and pharmaceutically acceptable acid;
- and alkali metal addition salts thereof.
3 more elements
A method of controlling hyperlipidemia in mammals which comprises administering to said mammal an effective amount for controlling hyperlipidemia of a compound of the formula:
- ##STR3## wherein X is aryl, cycloalkyl, or cycloalkylene containing up to ten carbon atoms;
- Y is CH or N;
- Z is alkyl containing up to five carbon atoms, carboxyl, carboalkoxy wherein the alkyl group contains up to four carbon atoms, acyl containing up to four carbon atoms, alkylene, aryl, aralkyl or aralkylene;
- n is 1 to 10;
- and further compounds wherein the group represented by X is replaced with at least one hydrogen on each of the carbon atoms adjacent the oxygen bearing functional groups and pharmaceutically acceptable acid;
- and alkali metal addition salts thereof.
3 more elements
Dependencies are inferred from the claim text.