Loading patent…
AssigneeDelalande S.A.
InventorsMichel Langlois, Bernard P. Bucher, Philippe L. Dostert, Alain P. Lacour, Gerard H. Moinet
Estimating the term…
Derivatives of formula: ##STR1## in which Z< represents: either an amino group of struture >N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case: n=1 or 2, the pair (A, C X) assumes the following values: (S, C.dbd.O), (S, CH.sub.2), (O, CH.sub.2), (O, CH--C.sub.6 H.sub.5), and R represents a hydrogen or halogen atom, one or more methoxy groups or the butadiene-1,3 ylene chain ##STR2## fixed in position 5,6 of the phenyhl nucleus and thus forming with this latter a naphthyl nucleus; or a methylene group (--CH.sub.2 --), in which case: n=1 or 2, A represents the oxygen atom, >C X represents a carbonyl group (>C.dbd.O) or thiocarbonyl group (>C.dbd.S), and R has the same meanings as previously, as well as the mineral or organic acid addition salts thereof. The compounds exhibit anti-convulsion and analgesic activity.
A compound of the formula ##STR36## in which Z is >N--R.sub.1 or --CH.sub.2 --, wherein R.sub.1 is alkyl having 1 to 5 carbon atoms, phenyl or chlorophenyl, and in which
A compound of the formula ##STR38## wherein n is 1 or 2, R.sub.1 is alkyl having 1 to 5 carbon atoms, phenyl or chlorophenyl, and R is hydrogen, halogen, one or two methoxy groups or --CH.dbd.CH--CH.dbd.CH-- connected to the 5 and 6 positions of the phenyl nucleus whereby to form a naphthyl nucleus.
A process for preparing a compound of the formula ##STR39## in which R.sub.1 is alkyl having 1 to 5 carbon atoms, phenyl or chlorophenyl, n is 1 or 2, and R is hydrogen, halogen, one or two methoxy groups or --CH.dbd.CH--CH.dbd.CH-- connected to the 5 and 6 positions of the phenyl nucleus whereby to form a naphthyl nucleus, which comprises reacting a compound of the formula ##STR40## with phosphorus pentasulfide, in the presence of a base.
A process for preparing a compound of the formula ##STR41## in which the pair (C X, A) is selected from the group consisting of (CH.sub.2, O), (CH--C.sub.6 H.sub.5, O) and (CH.sub.2, S), R.sub.1 is alkyl having 1 to 5 carbon atoms, phenyl or chlorophenyl, n is 1 or 2, and R is hydrogen, halogen, one or two methoxy groups or --CH.dbd.CH--CH.dbd.CH-- connected to the 5 and 6 positions of the phenyl nucleus whereby to form a naphthyl nucleus, which comprises condensing the lithium derivative of a compound of the formula ##STR42## in which R has the same meaning as defined above, and the pair (A, R.sub.2) is selected from the group consisting of (S, H), (O, H) and (O, C.sub.6 H.sub.5), with a compound of the formula ##STR43## in which R.sub.1 and n have the same meanings as defined above.
A process for preparing a compound of the formula ##STR44## in which n is 1 or 2, and R is hydrogen, halogen, one or two methoxy groups, or --CH.dbd.CH--CH.dbd.CH-- connected to the 5 and 6 positions of the phenyl nucleus whereby to form a naphthyl nucleus, which comprises condensing the lithium derivative of a compound of the formula ##STR45## in which R has the same meaning as defined above, with a compound of the formula ##STR46##
A process for preparing a compound of the formula ##STR47## in which n is 1 or 2, and R is hydrogen, halogen, one or two methoxy groups, or --CH.dbd.CH--CH.dbd.CH-- connected to the 5 and 6 positions of the phenyl nucleus whereby to form a naphthyl nucleus, which comprises reacting a compound of the formula ##STR48## in which n and R have the same meanings as defined above, with phosphorus pentasulfide.
An analgesic or anticonvulsant composition comprising a therapeutically effective amount of a compound of the formula ##STR49## in which Z is >N--R.sub.1 or --CH.sub.2 --, wherein R.sub.1 is alkyl having 1 to 5 carbon atoms, phenyl or chlorophenyl, and in which
Dependencies are inferred from the claim text.