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US 4,395,410 AGranted
Quaternary ammonium antiarrhythmic drugs
AssigneeEli Lilly and Company
InventorsBryan B. Molloy, Mitchell I. Steinberg
Life of this patent
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Abstract
Quaternary ammonium salts of certain phenylpropylamines and phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.
Claims13
A compound having the general formula ##STR3## wherein:
- n is 1 or 2;
- R.sup.1 is hydrogen or C.sub.1 -C.sub.2 alkyl;
- R.sup.2 is hydrogen or C.sub.1 -C.sub.3 alkyl;
- R.sup.3 is C.sub.1 -C.sub.4 alkyl or phenyl C.sub.1 -C.sub.4 alkyl;
- R.sup.4 and R.sup.5 taken together with the adjacent nitrogen to which they are attached complete a heterocyclic ring having 4 to 7 carbon atoms;
- R.sup.6 and R.sup.7 independently are hydrogen, hydroxy, halogen, nitro, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkyl, provided that at least one of R.sup.6 and R.sup.7 is hydrogen, and
- X is a therapeutically acceptable anion.
4 more elements
Dependencies are inferred from the claim text.